affliction bad difficult discomfort grin hard harrowing heart-rending lousy painful rough sad terror troubled trying uncomfortable worse

guiltiness guilt

agonized agonizing agony bleeding choked hurt ordeal painfully sick sorrow stciky suffering suffer thorny tight unpleasant worry

care commiseration heartache misery misfortune trauma travail

misease penance stab taste twinge wrench

pang stound throe

blemish bruise cut gash scratch talk wart wound

arch fidget stir twist wiggle writhe

acrimonious bitter bother cruel miss piquant sorry spicy taxing tough unbearable

sore threat vulnerable

anguish

dolour grief lamentation ruth sadness tristesse unhappiness

bestial relentless unfeeling

demand load

ask funding liability onus share strain

complication disaster episode hell inconvenience irritating misadvenature moil nuisance problem trouble

affair agenda aspect bone business challenge choice concern conversation count difficulty dirt element fact flap idea interest issue matter nature palaver point problematically product proposition question reason reference responsibility risk scrape story subject term thing topic troublesome

pain-filled pained painfully painful painkiller painstakingly painstaking paint